Research Publications

Below is a sampling of scientific papers that relate to FTD. They are listed by topic, with most recent article first. We deeply appreciate the efforts of all of the scientists around the globe who are working to better understand, more accurately diagnose and develop treatments for FTD. For a comprehensive list, we encourage you to go to PubMed (see link below) where you can search by author or keyword and download abstracts or full articles. If you know of a key paper that is not listed here, please contact AFTD with the information.

To find original scientific articles online:

PubMed, a service of the National Library of Medicine, National Institutes of Health, provides access to MEDLINE citations and includes links to many sites providing full text articles and other related resources. At PubMed Central (embed this link: http://www.pubmedcentral.nih.gov/)  search for Pick’s Disease, frontotemporal dementia, Lewy Body, etc.

General

American Journal of Alzheimer’s Disease & Other Dementias, December 2007/January 2008 Issue (Vol 22 Number 6). This entire issue was dedicated to Frontotemporal Dementia .

Alzheimer Dis Assoc Disord 2007;21:S3-S4. Identification and Characterization of Frontal Lobe Degeneration: Historical Perspective on the Development of FTD. Brun A.

Alzheimer’s Care Quarterly, July/September 2005 issue on Atypical Dementias published by Lippincott Wilkins Williams, Carol Bowlby Sifton, Editor. This issue focuses on frontotemporal dementia, with a variety of articles about FTD written for the lay public, including one by an FTD patient.

Diagnosis and Course of FTD

Rosness TA, Haugen PK, Passant U, Engedal K. Frontotemporal dementia: a clinically complex diagnosis. Int J Geriatr Psychiatry. 2008 Aug;23(8):837-42.

Rascovsky K, Hodges JR, Kipps CM, Johnson JK, Seeley WW, et al. . Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directions. Alzheimer Dis Assoc Disord. 2007 Oct-Dec;21(4):S14-8

Kertesz A, Blair M, McMonagle P, Munoz DG. The diagnosis and course of frontotemporal dementia. Alzheimer Dis Assoc Disord. 2007 Apr-Jun;21(2):155-63.

Cairns, N, Bigio, E, Mackenzie, I, Neumann, M, et al. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration Acta Neuropathol. May 2007

Boxer AL, Miller BL. Clinical features of frontotemporal dementia. Alzheimer Dis Assoc Disord. 2005 Oct-Dec;19 Suppl 1:S3-6. Review. PMID: 16317256 [PubMed - indexed for MEDLINE]

McKhann, G., Trojanowski, J.Q., Grossman, M., Miller, B.L., Dickinson, D., & Albert, M. (2001). Clinical and pathological diagnosis of Frontotemporal dementia: Report of a work group on Frontotemporal dementia and Pick’s disease. Archives of Neurology, 58, 1803-1809.

Therapeutic Intervention

Mendez MF. Frontotemporal dementia: therapeutic interventions. Front Neurol Neurosci. 2009;24:168-78. Epub 2009 Jan 26.

Trojanowski, J. Q., Duff K., Fillit H, et al. New directions for frontotemporal dementia drug discovery. Alzheimer’s & Dementia (2008) 89-93

Boxer AL, Boeve BF. Frontotemporal dementia treatment: current symptomatic therapies and implications of recent genetic, biochemical, and neuroimaging studies. Alzheimer Dis Assoc Disord. 2007 Oct-Dec;21(4):S79-87.

Knopman DS, Boeve BS, Caselli RJ, Graff-Radford NR, Kramer JH, Mendez MF, Miller BL. Longitudinal tracking of FTLD: toward developing clinical trial methodology. Alzheimer Dis Assoc Disord. 2007 Oct-Dec;21(4):S58-63.

Mendez MF, Shapira JS, McMurtray A, Licht E, Miller BL. Accuracy of the clinical evaluation for frontotemporal dementia. Arch Neurol. 2007 Jun;64(6):830-5.

Kipps CM, Nestor PJ, Dawson CE, Mitchell J, Hodges JR. Measuring progression in frontotemporal dementia: implications for therapeutic interventions. Neurology. 2008 May 27;70(22):2046-52.

Freedman M. Frontotemporal dementia: recommendations for therapeutic studies, designs, and approaches. Can J Neurol Sci. 2007 Mar;34 Suppl 1:S118-24.

Genetics of FTD

Kwiatkowski T. J., et al. Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis Science 323, 1205 (2009)

Vance C, et al. Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6. Science 323, 1208 (2009)

Baker M, Mackenzie I.R., Pickering-Brown S.M. et al. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature, July 2006

Cruts M., Gijselinck I., van der Zee J. Null mutations in progranulin cause ubiquitinpositive frontotemporal dementia linked to chromosome 17q21. Nature, July 2006

Goldman JS, Farmer JM, Wood EM, Johnson JK, Boxer A, Neuhaus J, Lomen-Hoerth C, Wilhelmsen KC, Lee VM, Grossman M, Miller BL. Comparison of family histories in FTLD subtypes and related tauopathies. Neurology. 2005 Dec 13;65(11):1817-9

Social Issues

Papatriantafyllou JD, Viskontas IV, Papageorgiou SG, Miller BL, Pavlic D, Bingol A, Yener G. Difficulties in detecting behavioral symptoms of frontotemporal lobar degeneration across cultures. Alzheimer Dis Assoc Disord. 2009 Jan-Mar;23(1):77-81.

Viskontas IV, Possin KL, Miller BL. Symptoms of frontotemporal dementia provide insights into orbitofrontal cortex function and social behavior. Ann N Y Acad Sci. 2007 Dec;1121:528-45. Epub 2007 Sep 10.